2614W94 is a selective, reversible inhibitor of monoamine oxidase-A with a competitive mechanism of inhibition and IC50 of 5 nM and Ki of 1.6 nM with serotonin as substrate.

Product information

CAS Number: 205187-35-5

Molecular Weight: 344.31

Formula: C15H11F3O4S

Chemical Name: 3-[(1,1,1-trifluoropropan-2-yl)oxy]-10λ⁶-phenoxathiine-10,10-dione

Smiles: CC(OC1=CC2OC3C=CC=CC=3S(=O)(=O)C=2C=C1)C(F)(F)F

InChiKey: ZWKJZNQUILFRHJ-UHFFFAOYSA-N

InChi: InChI=1S/C15H11F3O4S/c1-9(15(16,17)18)21-10-6-7-14-12(8-10)22-11-4-2-3-5-13(11)23(14,19)20/h2-9H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.

In Vivo:

2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED50 of 1.1 mg/kg.

Products are for research use only. Not for human use.